The Brenham Heritage Museum is a local history museum in downtown Brenham, Texas located in the former US Post Office-Federal Building-Brenham listed on the National Register of Historic Places building. The museum is operated by the Brenham Heritage Museum Board of Directors, and staff members. The museum operates a second site, the Bus Depot Gallery, in the Art-Deco Kerrville Bus Lines Depot of Brenham.